{"id":17179,"date":"2024-10-22T02:00:01","date_gmt":"2024-10-22T09:00:01","guid":{"rendered":"https:\/\/softwareengineeringdaily.com\/?p=17179"},"modified":"2024-10-21T05:01:04","modified_gmt":"2024-10-21T12:01:04","slug":"engineering-an-open-source-crispr-with-aadyot-bhatnagar","status":"publish","type":"post","link":"https:\/\/softwareengineeringdaily.com\/2024\/10\/22\/engineering-an-open-source-crispr-with-aadyot-bhatnagar\/","title":{"rendered":"Engineering an Open Source CRISPR with Aadyot Bhatnagar"},"content":{"rendered":"<div style=\"text-align: justify;\">\n<p>CRISPR is a powerful tool in biotechnology that allows scientists to precisely edit genes, much like editing lines of code in a computer program. Just as developers can remove or alter specific parts of a code to fix bugs or enhance functionality, CRISPR enables researchers to modify DNA to correct genetic disorders, improve crops, or develop new treatments. The development of CRISPR-based editing was recognized by the Nobel Prize in Chemistry in 2020 awarded to Emmanuelle Charpentier and Jennifer Doudna.<\/p>\n<\/div>\n<div style=\"text-align: justify;\">\n<p><a href=\"https:\/\/twitter.com\/ProfluentBio\">Profluent Bio<\/a> is an AI-first protein design company that recently developed OpenCRISPR-1, which is an AI-generated, CRISPR-like protein that does not occur in nature. Importantly, the company also released the protein and nucleic acid sequences for OpenCRISPR-1.<\/p>\n<\/div>\n<div style=\"text-align: justify;\">\n<p><a href=\"https:\/\/www.linkedin.com\/in\/abhatnagar6\/\">Aadyot Bhatnagar<\/a> is an ML Scientist at Profluent Bio and previously worked at Salesforce. He joins the podcast with Sean Falconer to talk about OpenCRISPR-1 and how it was made.<\/p>\n<\/div>\n<div style=\"text-align: justify;\">\n<p><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\"><a href=\"https:\/\/i0.wp.com\/softwareengineeringdaily.com\/wp-content\/uploads\/2023\/10\/Rectangle-3-2.png\"><img fetchpriority=\"high\" decoding=\"async\" data-attachment-id=\"15613\" data-permalink=\"https:\/\/softwareengineeringdaily.com\/2023\/10\/24\/streamlit-with-amanda-kelly\/rectangle-3-3\/\" data-orig-file=\"https:\/\/i0.wp.com\/softwareengineeringdaily.com\/wp-content\/uploads\/2023\/10\/Rectangle-3-2.png?fit=218%2C258&amp;ssl=1\" data-orig-size=\"218,258\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Rectangle 3\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/softwareengineeringdaily.com\/wp-content\/uploads\/2023\/10\/Rectangle-3-2.png?fit=218%2C258&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/softwareengineeringdaily.com\/wp-content\/uploads\/2023\/10\/Rectangle-3-2.png?fit=218%2C258&amp;ssl=1\" class=\"size-full wp-image-15613 alignleft\" src=\"https:\/\/i0.wp.com\/softwareengineeringdaily.com\/wp-content\/uploads\/2023\/10\/Rectangle-3-2.png?resize=218%2C258&#038;ssl=1\" alt=\"\" width=\"218\" height=\"258\" data-recalc-dims=\"1\" \/><img class=\"\" alt=\"\" width=\"\" height=\"\" \/><\/a>Sean&#8217;s been an academic, startup founder, and Googler. He has published works covering a wide range of topics from information visualization to quantum computing. Currently, Sean is Head of Marketing and Developer Relations at <a>Skyflow<\/a> and host of the podcast Partially Redacted, a podcast about privacy and security engineering. You can connect with Sean on Twitter <a>@seanfalconer.<\/a><\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<div style=\"text-align: justify;\">\n<div style=\"text-align: left;\">\n<p><a href=\"http:\/\/softwareengineeringdaily.com\/wp-content\/uploads\/2024\/10\/SED1753-Profluent.txt\">Please click here to see the transcript of this episode.<\/a><\/p>\n<\/div>\n<\/div>\n<div style=\"text-align: justify;\">\n<p style=\"text-align: left;\">Sponsorship inquiries: <a href=\"https:\/\/cms.megaphone.fm\/organizations\/619b680e-d813-11ea-9750-e7ecac406436\/podcasts\/e60108fe-e328-11ea-b2b6-1348249f900a\/episodes\/3913370a-bc44-11ed-ace6-8b1f96d82bba\/sponsor@softwareengineeringdaily.com\">sponsor@softwareengineeringdaily.com<\/a><\/p>\n<\/div>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>CRISPR is a powerful tool in biotechnology that allows scientists to precisely edit genes, much like editing lines of code in a computer program. Just as developers can remove or alter specific parts of a code to fix bugs or enhance functionality, CRISPR enables researchers to modify DNA to correct genetic disorders, improve crops, or<\/p>\n","protected":false},"author":94,"featured_media":17180,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[1363,2143,5755,14,5760],"tags":[6466,6463,1113,6464,6465],"class_list":["post-17179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all-episodes","category-exclusive-content","category-hosts","category-podcast","category-sean-falconer","tag-aadyot-bhatnagar","tag-biotechnology","tag-crispr","tag-gene-editing","tag-profluent-bio"],"jetpack_publicize_connections":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Engineering an Open Source CRISPR with Aadyot Bhatnagar - Software Engineering Daily<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/softwareengineeringdaily.com\/2024\/10\/22\/engineering-an-open-source-crispr-with-aadyot-bhatnagar\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Engineering an Open Source CRISPR with Aadyot Bhatnagar - Software Engineering Daily\" \/>\n<meta property=\"og:description\" content=\"CRISPR is a powerful tool in biotechnology that allows scientists to precisely edit genes, much like editing lines of code in a computer program. 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